Lactation is the whole process of breastfeeding, starting from breast milk production until the baby sucks and swallows breast milk. Based on interviews with 20 postpartum mothers, 15 mothers said breast milk was not smooth and 5 mothers had smooth breastfeeding, postpartum mothers did not have smooth breastfeeding when the breastfeeding process appeared difficult because the baby cried because breast milk was not available. Papaya leaf powder is a method that can stimulate an increase in breastfeeding because the body releases the hormone prolactin for the formation of ASI gland. Research has known the effect of papaya leaf powder on the smoothness of breast milk in postpartum mothers. The aim of the researchers was to determine the effect of papaya leaf powder on the smoothness of breast milk in postpartum mothers in Paradise Maternity Hospital Simpang Empat District, Tanah Bumbu Regency. The research design used Quasi Experiment with Pre And Post Test Without Control. The samples in this study were 20 breastfed mothers not smoothly with Purposive Sampling technique. The result of research using Wilcoxon test got p value <0,05 (0,001) meaning that there is influence of papaya leaf powder to smoothness of breast milk in postpartum mother. The conclusion of this research is the effect of papaya leaf powder on the smoothness of breast milk in postpartum mother. It is recommended that papaya leaf powder is used as a method in midwifery care for postpartum especially to expedite breast feeding papaya leaf.